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1

Safety and Efficacy of Tofacitinib in Patients with Active Psoriatic Arthritis: Interim Analysis of OPAL Balance, an Open-Label, Long-Term Extension Study

Nash, Peter, Coates, Laura C., Kivitz, Alan J., Mease, Philip J., Gladman, Dafna D., Covarrubias-Cobos, JosÃ© A., FitzGerald, Oliver, Fleishaker, Dona, Wang, Cunshan, Wu, Joseph, Hsu, Ming-Ann, Menon,

Journal:

Rheumatology and Therapy

Year:

2020

File:

PDF, 2.88 MB

2020

2

Factors affecting the milk-to-plasma drug concentration ratio in lactating women: Physical interactions with protein and fat

Joseph C. Fleishaker, Nirmala Desai, Patrick J. McNamara

Journal:

Journal of Pharmaceutical Sciences

Year:

1987

Language:

english

File:

PDF, 605 KB

english, 1987

3

The Selective Norepinephrine Reuptake Inhibitor Antidepressant Reboxetine: Pharmacological and Clinical Profile

Mihály Hajós, Joseph C. Fleishaker, Jacqueline K. Filipiak-Reisner, Mark T. Brown, Erik H. F. Wong

Journal:

CNS Drug Reviews

Year:

2004

Language:

english

File:

PDF, 133 KB

english, 2004

4

Compartmental Model Analysis in Pharmacokinetics

Fleishaker, Joseph C., Smith, Randall B.

Journal:

Journal of Clinical Pharmacology

Year:

1987

Language:

english

File:

PDF, 866 KB

english, 1987

5

Induction of tirilazad clearance by phenytoin

Joseph C. Fleishaker, Laura K. Pearson, Gary R. Peters

Journal:

Biopharmaceutics & Drug Disposition

Year:

1998

Language:

english

File:

PDF, 135 KB

english, 1998

6

Absolute bioavailability of reboxetine enantiomers and effect of gender on pharmacokinetics

Joseph C. Fleishaker, Massimiliano Mucci, Cinzia Pellizzoni, Italo Poggesi

Journal:

Biopharmaceutics & Drug Disposition

Year:

1999

Language:

english

File:

PDF, 118 KB

english, 1999

7

Evaluation of the development of acute tolerance to the psychomotor effects of midazolam following intravenous infusions in healthy volunteers

Joseph C. Fleishaker, James H. Chambers, Gary R. Peters

Journal:

Human Psychopharmacology: Clinical and Experimental

Year:

1995

Language:

english

File:

PDF, 669 KB

english, 1995

8

Possible effect of lactational period on the milk-to-plasma drug concentration ratio in lactating women: Results of an in vitro evaluation

Joseph C. Fleishaker, Nirmala Desai, Patrick J. McNamara

Journal:

Journal of Pharmaceutical Sciences

Year:

1989

Language:

english

File:

PDF, 581 KB

english, 1989

9

Phenytoin causes a rapid increase in 6β-hydroxycortisol urinary excretion in humans—a putative measure of CYP3A induction

Joseph C. Fleishaker, Laura K. Pearson, Gary R. Peters

Journal:

Journal of Pharmaceutical Sciences

Year:

1995

Language:

english

File:

PDF, 325 KB

english, 1995

10

Alprazolam absorption kinetics affects abuse liability*

Mumford, Geoffrey K., Evans, Suzette M., Fleishaker, Joseph C., Griffiths, Roland R.

Journal:

Clinical Pharmacology & Therapeutics

Year:

1995

Language:

english

File:

PDF, 978 KB

english, 1995

11

Effect of MAO-A inhibition on the pharmacokinetics of almotriptan, an antimigraine agent in humans

Joseph C. Fleishaker, Kristi K. Ryan, Josep M. Jansat, Barabara J. Carel, David J. A. Bell, Moira T. Burke, Nkechi E. Azie

Journal:

British Journal of Clinical Pharmacology

Year:

2001

Language:

english

File:

PDF, 92 KB

english, 2001

12

N-desmethyladinazolam pharmacokinetics and behavioral effects following administration of 10–50 mg oral doses in healthy volunteers

Joseph C. Fleishaker, Thomas C. Smith, H. Friedman, J. Paul Phillips

Journal:

Psychopharmacology

Year:

1991

Language:

english

File:

PDF, 715 KB

english, 1991

13

The pharmacokinetics and pharmacodynamics of adinazolam: multi-ethnic comparisons

Kotra Ajir, Michael Smith, Keh-Ming Lin, Dora Anderson, Inocencia Nuccio, Yanping Zheng, Russell E. Poland, Joseph C. Fleishaker, James H. Chambers

Journal:

Psychopharmacology

Year:

1997

Language:

english

File:

PDF, 546 KB

english, 1997

14

Pharmacokinetics of reboxetine in healthy volunteers with different ethnic descents

Pamela E. Hendershot, Joseph C. Fleishaker, Keh-Ming Lin, Inocencia D. Nuccio, Russell E. Poland

Journal:

Psychopharmacology

Year:

2001

Language:

english

File:

PDF, 55 KB

english, 2001

15

Comparing Methods of Measurement for Detecting Drug-Induced Changes in the QT Interval: Implications for Thoroughly Conducted ECG Studies

Nkechi E. Azie, Gregory Adams, Borje Darpo, Steven F. Francom, Emery C. Polasek, Joy M. Wisser, Joseph C. Fleishaker

Journal:

Annals of Noninvasive Electrocardiology

Year:

2004

Language:

english

File:

PDF, 178 KB

english, 2004

16

Electrocardiographic Identification of Drug-Induced QT Prolongation: Assessment by Different Recording and Measurement Methods

Nenad Sarapa, Joel Morganroth, Jean-Philippe Couderc, Steven F. Francom, Borje Darpo, Joseph C. Fleishaker, Janet D. McEnroe, William T. Chen, Wojciech Zareba, Arthur J. Moss

Journal:

Annals of Noninvasive Electrocardiology

Year:

2004

Language:

english

File:

PDF, 246 KB

english, 2004

17

Pharmacokinetics of tirilazad and U-89678, an active, reduced metabolite, following acute head trauma in adults.

Joseph C. Fleishaker, Robert N. Straw, Carol J. Cross

Journal:

Journal of Pharmaceutical Sciences

Year:

1997

Language:

english

File:

PDF, 96 KB

english, 1997

18

Clinical pharmacology of adinazolam and N-desmethyladinazolam mesylate after single oral doses of each compound in healthy volunteers

Fleishaker, Joseph C, Friedman, H, Pollock, Steven R, Smith, Thomas C

Journal:

Clinical Pharmacology & Therapeutics

Year:

1990

Language:

english

File:

PDF, 866 KB

english, 1990

19

Effect of age and gender on tirilazad pharmacokinetics in humans

Hulst, Laura K, Fleishaker, Joseph C, Peters, Gary R, Harry, John D, Wright, D Mark, Ward, Penelope

Journal:

Clinical Pharmacology & Therapeutics

Year:

1994

Language:

english

File:

PDF, 912 KB

english, 1994

20

In Vitroandin VivoEvaluation of Whole and Half Tablets of Sustained-Release Adinazolam Mesylate

John W. Skoug, Marie T. Borin, Joseph C. Fleishaker, Anne M. Cooper

Journal:

Pharmaceutical Research

Year:

1991

File:

PDF, 1.20 MB

1991

21

Pharmacokinetic and Pharmacodynamic Comparison of Immediate-Release and Sustained-Release Adinazolam Mesylate Tablets After Single- and Multiple-Dose Administration

Joseph C. Fleishaker, C. Eugene Wright

Journal:

Pharmaceutical Research

Year:

1992

File:

PDF, 1.18 MB

1992

22

Extent and Variability of the First-Pass Elimination of Adinazolam Mesylate in Healthy Male Volunteers

Joseph C. Fleishaker, H. Friedman, Steven R. Pollock

Journal:

Pharmaceutical Research

Year:

1991

File:

PDF, 989 KB

1991

23

Population Pharmacokinetics of Tirilazad: Effects of Weight, Gender, Concomitant Phenytoin, and Subarachnoid Hemorrhage

Joseph C. Fleishaker, Jill Fiedler-Kelly, Thaddeus H. Grasela

Journal:

Pharmaceutical Research

Year:

1999

File:

PDF, 1.45 MB

1999

24

Lack of Pharmacokinetic Interaction Between Cimetidine and Tirilazad Mesylate

Joseph C. Fleishaker, Laura K. Hulst, Gary R. Peters

Journal:

Pharmaceutical Research

Year:

1994

File:

PDF, 599 KB

1994

25

Mean residence time in peripheral tissue

Patrick J. McNamara, Joseph C. Fleishaker, Thomas L. Hayden

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1987

Language:

english

File:

PDF, 640 KB

english, 1987

26

Models and methods for predicting drug transfer into human milk

Joseph C. Fleishaker

Journal:

Advanced Drug Delivery Reviews

Year:

2003

Language:

english

File:

PDF, 168 KB

english, 2003

27

Multiple-Dose Pharmacokinetics and Pharmacodynamics of Adinazolam in Elderly Subjects

Joseph C. Fleishaker, J. Paul Phillips, Thomas C. Smith, Randall B. Smith

Journal:

Pharmaceutical Research

Year:

1989

File:

PDF, 1.31 MB

1989

28

Studies with [11C]alprazolam: an agonist for the benzodiazepine receptor

Frank R. Dobbs, William Banks, Joseph C. Fleishaker, Alan D. Valentine, Berma M. Kinsey, Mark P. Franceschini, George A. Digenis, Timothy J. Tewson

Journal:

Nuclear Medicine and Biology

Year:

1995

Language:

english

File:

PDF, 718 KB

english, 1995

29

Kinetic Characterization and Identification of the Enzymes Responsible for the Hepatic Biotransformation of Adinazolam and N-Desmethyladinazolam in Man

Karthik Venkatakrishnan, Lisa L. Von Moltke, Su Xiang Duan, Joseph C. Fleishaker, Richard I. Shader, David J. Greenblatt

Journal:

Journal of Pharmacy and Pharmacology

Year:

1998

Language:

english

File:

PDF, 930 KB

english, 1998

30

Clinical Pharmacokinetics of Reboxetine, a Selective Norepinephrine Reuptake Inhibitor for the Treatment of Patients with Depression

Dr Joseph C. Fleishaker

Journal:

Clinical Pharmacokinetics

Year:

2000

Language:

english

File:

PDF, 216 KB

english, 2000

31

Clinical Pharmacokinetics of Almotriptan, a Serotonin 5-HT1B/1DReceptor Agonist for the Treatment of Migraine

Janet D. McEnroe, Dr Joseph C. Fleishaker

Journal:

Clinical Pharmacokinetics

Year:

2005

Language:

english

File:

PDF, 153 KB

english, 2005

32

Evaluation of the Potential Pharmacokinetic/Pharmacodynamic Interaction between Fluoxetine and Reboxetine in Healthy Volunteers

Dr Joseph C. Fleishaker, Beth D. Herman, Laura K. Pearson, Antoaneta Ionita, Massimiliano Mucci

Journal:

Clinical Drug Investigation

Year:

1999

Language:

english

File:

PDF, 202 KB

english, 1999

33

Separation of the Pharmacokinetic/Pharmacodynamic Properties of Oral and IV Adinazolam Mesylate andN-Desmethyladinazolam Mesylate in Healthy Volunteers

Dr Joseph C. Fleishaker,T. C. Smith,H. L. Friedman,L. K. Hulst

Journal:

Clinical Drug Investigation

Year:

1992

Language:

english

File:

PDF, 1.54 MB

english, 1992

34

Interaction between Ketoconazole and Almotriptan in Healthy Volunteers

Fleishaker, Joseph C., Herman, Beth D., Carel, Barbara J., Azie, Nkechi E.

Journal:

Journal of Clinical Pharmacology

Year:

2003

Language:

english

File:

PDF, 144 KB

english, 2003

35

Performance Characteristics for Some Typical QT Study Designs Under the ICH E-14 Guidance

Hutmacher, Matthew M., Chapel, Sunny, Agin, Marilyn A., Fleishaker, Joseph C., Lalonde, Richard L.

Journal:

Journal of Clinical Pharmacology

Year:

2008

Language:

english

File:

PDF, 380 KB

english, 2008

36

Effects of Acute and Chronic Alprazolam Treatment on Cerebral Blood Flow, Memory, Sedation, and Plasma Catecholamines

Roy-Byre, Peter, Fleishaker, Joseph, Arnett, Carroll, Dubach, Mark, Stewart, Jodi, Radant, Allen, Veith, Richard, Graham, Michael

Journal:

Neuropsychopharmacology

Year:

1993

Language:

english

File:

PDF, 899 KB

english, 1993

37

Lack of a Pharmacokinetic/Pharmacodynamic Interaction Between Nimodipine and Tirilazad Mesylate in Healthy Volunteers

Fleishaker, Joseph C., Hulst, Laura K., Peters, Gary R.

Journal:

Journal of Clinical Pharmacology

Year:

1994

Language:

english

File:

PDF, 767 KB

english, 1994

38

The effect of phenytoin on the pharmacokinetics of tirilazad mesylate in healthy male volunteers

Fleishaker, Joseph C, Hulst, Laura K, Peters, Gary R

Journal:

Clinical Pharmacology & Therapeutics

Year:

1994

Language:

english

File:

PDF, 627 KB

english, 1994

39

Evaluation of the Potential Pharmacokinetic Interaction between Almotriptan and Fluoxetine in Healthy Volunteers

Fleishaker, Joseph C., Ryan, Kristi K., Carel, Barbara J., Azie, Nkechi E.

Journal:

Journal of Clinical Pharmacology

Year:

2001

Language:

english

File:

PDF, 101 KB

english, 2001

40

Kinetics and Dynamics of Intravenous Adinazolam, N-Desmethyl Adinazolam, and Alprazolam in Healthy Volunteers

Venkatakrishnan, Karthik, Culm, Kerry E., Ehrenberg, Bruce L., Harmatz, Jerold S., Corbett, Kathleen E., Fleishaker, Joseph C., Greenblatt, David J.

Journal:

Journal of Clinical Pharmacology

Year:

2005

Language:

english

File:

PDF, 185 KB

english, 2005

41

Comparison of Adinazolam Pharmacokinetics and Effects in Healthy and Cirrhotic Subjects

Kroboth, Patricia D., BS, Rae Ann Maxwell, Fleishaker, Joseph C., Van Thiel, David H., Smith, Randall B.

Journal:

Journal of Clinical Pharmacology

Year:

1991

Language:

english

File:

PDF, 998 KB

english, 1991

42

Disposition of Minoxidil in Patients with Various Degrees of Renal Function

Halstenson, Charles E., Opsahl, John A., Wright, C. Eugene, Fleishaker, Joseph C., Andreadis, N. A., Sobieraj, Jadwiga, Matzke, Gary R.

Journal:

Journal of Clinical Pharmacology

Year:

1989

Language:

english

File:

PDF, 1006 KB

english, 1989

43

Pharmacokinetics of Single-Dose Reboxetine in Volunteers with Renal Insufficiency

Coulomb, François, Ducret, Francis, Laneury, Jean-Paul, Fiorentini, Francesco, Poggesi, Italo, Jannuzzo, M. Gabriella, Fleishaker, Joseph C., Houin, Georges, Duchêne, Patrick

Journal:

Journal of Clinical Pharmacology

Year:

2000

Language:

english

File:

PDF, 828 KB

english, 2000

44

Anticipatory Anxiety in Moderately to Highly-Anxious Oral Surgery Patients as a Screening Model for Anxiolytics: Evaluation of Alprazolam

Wolf, Daniel L., Desjardins, Paul J., Black, Peter M., Francom, Steven R., Mohanlal, Ramon W., Fleishaker, Joseph C.

Journal:

Journal of Clinical Psychopharmacology

Year:

2003

Language:

english

File:

PDF, 450 KB

english, 2003

45

Pharmacokinetics and Pharmacodynamics of Adinazolam and N-Desmethyladinazolam after Oral and Intravenous Dosing in Healthy Young and Elderly Volunteers

FLEISHAKER, JOSEPH C., HULST, LAURA K., EKERN??S, SVEN-??AKE, GRAHN??N, ANDERS

Journal:

Journal of Clinical Psychopharmacology

Year:

1992

File:

PDF, 910 KB

1992

46

Pharmacokinetics and Psychomotor Performance of Alprazolam: Concentration-Effect Relationship

Wright, C. Eugene, Sisson, Theresa Lasher, Fleishaker, Joseph C., Antal, Edward J.

Journal:

Journal of Clinical Pharmacology

Year:

1997

Language:

english

File:

PDF, 1.41 MB

english, 1997

47

Valdecoxib, a COX-2-Specific Inhibitor, Does Not Affect Cardiac Repolarization

Sarapa, Nenad, Britto, Margaret R., Cotton, Barbara, Cox, Steven R., Francom, Steven F., Jin, Na, Polasek, Emery D., Sainati, Stephen M., Crosby-Sessoms, Sharon L., Fleishaker, Joseph C.

Journal:

Journal of Clinical Pharmacology

Year:

2003

Language:

english

File:

PDF, 124 KB

english, 2003

48

Psychomotor and Memory Effects of Two Adinazolam Formulations Assessed by a Computerized Neuropsychological Test Battery

Fleishaker, Joseph C., Sisson, Theresa A., Sramek, John J., Conrad, Julie, Verof, Amy E., Cutler, Neal R.

Journal:

Journal of Clinical Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.10 MB

english, 1993

49

Pharmacokinetics of Tirilazad and U-89678 in Ischemic Stroke Patients Receiving a Loading Regimen and Maintenance Regimen of 10 mg/kg/day of Tirilazad

Fleishaker, Joseph C., Peters, Gary R.

Journal:

Journal of Clinical Pharmacology

Year:

1996

Language:

english

File:

PDF, 781 KB

english, 1996

50

Evaluation of a Potential Interaction Between Erythromycin and Glyburide in Diabetic Volunteers

Fleishaker, Joseph C., Phillips, J. Paul

Journal:

Journal of Clinical Pharmacology

Year:

1991

Language:

english

File:

PDF, 391 KB

english, 1991